General Cell Based Assays
Abcam Lovastatin (Mevinolin), HMG-CoA reductase inhibitor, 10MG
MW 404.5 Da, Purity >98%. Potent, competitive HMG-CoA reductase inhibitor (Ki = 0.6 nM). Blood-brain barrier permeable. Inhibits in vivo and in vitro cholesterol biosynthesis. Also reduces α-synuclein levels in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter eXpress CCKAR CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0190E2CP2L)
The PathHunter CCKAR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. cholecystokinin) based activation of CCKAR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCKAR and EA-tagged β-Arrestin-2. Activation of CCKAR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter CCR2 Bioassay Kit, 2-Plate. (93-0192Y2-00061)
The PathHunter CCR2 Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. MCP-1/CCL2) based activation of CCR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCR2 and EA-tagged β-Arrestin-2. Activation of CCR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Eurofins Discoverx PathHunter eXpress OXGR1 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0693E2CP1L)
The PathHunter OXGR1 (GPR80, GPR99) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of OXGR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged OXGR1 and EA-tagged β-Arrestin-2. Activation of OXGR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress MC4R CHO-K1 GPCR Assay, 2-Plate Kit. (95-0050E2CP2M)
The cAMP Hunter MC4R eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. α-melanocyte stimulating hormone) based activation of MC4R GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type MC4R, a naturally Gs coupled GPCR. Upon activation of MC4R, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
American Research Products Inc FOXD3 Transcription Factor Activity Assay
FOXD3 Transcription Factor Activity Assay
Meso Scale Discovery R-PLEX Rat TNF- ASY
The R-PLEX Rat TNF-alpha Assay Kit from Meso Scale Discovery is a multiplex immunoassay that measures TNF-alpha in rat serum plasma and cell culture supernatants The assay uses electrochemiluminescence (ECL) detection technology and provides high sensitivity broad dynamic range and requires low sample volume The kit includes a 96-well plate coated with capture antibody detection antibody read buffer wash buffer blocker reagents and calibrator The assay has a typical sensitivity of 0 3 pg/mL and an upper limit of quantitation of 10 000 pg/mL It requires 25 L of sample and can assay 46 samples in duplicate The kit has high specificity and no cross-reactivity
Meso Scale Discovery R-PLEX Human MMP-8 ASY
The R-PLEX Human MMP-8 Assay Kit from Meso Scale Discovery is a multiplex immunoassay that measures MMP-8 protein levels in human serum plasma saliva and cell culture supernatants The assay uses electrochemiluminescence (ECL) detection technology and provides high sensitivity broad dynamic range and requires low sample volume The kit includes a 96-well plate coated with capture antibody detection antibody read buffer wash buffer blocker solutions calibrator and controls The assay has a typical sensitivity of 0 08 ng/mL and an upper limit of quantification of 1500 ng/mL
Eurofins Discoverx PathHunter eXpress mADCYAP1R1 (PAC1) CHO-K1 β-Arrestin GPCR Assay, 2pl Kit. (93-0594E2MCP0M)
The PathHunter mADCYAP1R1 (PAC1) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. PACAP) based activation of mADCYAP1R1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mADCYAP1R1 and EA-tagged β-Arrestin-2. Activation of mADCYAP1R1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Human SDF-1 alpha (CXCR4) β-Arrestin Cell-Based Assay Kit (C2C12)
The PathHunter Human SDF-1 alpha (CXCR4) β-Arrestin Stable Cell Line Assay (C2C12) contains a stable clonal cell line used to measure CXCR4 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Discovery Life Sciences Gentest Cryo White Rabbit Hep
Gentest Cryopreserved New Zealand White Rabbit Hepatocytes Female plateable
Discovery Life Sciences Gentest Sprague DawlRat Hep
Gentest Sprague Dawley Rat Hepatocytes Cryopreserved Male Plateable Inducible
Eurofins Discoverx PathHunter eXpress LHCGR CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0957E2CP0L)
The PathHunter LHCGR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. luteinizing hormone) based activation of LHCGR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged LHCGR and EA-tagged β-Arrestin-2. Activation of LHCGR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Meso Scale Discovery U-PLEX Mouse IL-2 ASY
The Meso Scale Discovery U-PLEX Mouse IL-2 Assay Kit is a sensitive immunoassay for detecting and quantifying mouse interleukin 2 (IL-2) in various biological fluids It uses MSD s electrochemiluminescent technology and includes plates with capture antibodies detection antibodies calibrators and buffers for 96 tests With a sensitivity of 0 06 pg/mL and a range of 0 06-1500 pg/mL it requires only 25 L of sample and provides results in 3 5 hours Ideal for mouse vaccine studies immunotherapy research and cytokine profiling
Meso Scale Discovery U-PLEX Mouse IL-6 ASY
The Meso Scale Discovery U-PLEX Mouse IL-6 Assay Kit is a multiplex immunoassay for measuring mouse interleukin 6 (IL-6) in various biological samples It uses electrochemiluminescence (ECL) detection for high sensitivity and precision The kit includes a 96-well plate with capture antibodies ECL-tagged detection antibodies calibrators and diluent The assay takes about 3 5 hours and requires a Meso Scale Discovery instrument It detects IL-6 with a lower limit of 0 3 pg/mL allowing quantitation across a wide range